Mechanism of Baoyuan Decoction in the Treatment of Chronic Heart Failure Based on Network Pharmacology

This study aims to explore the material basis and mechanism of Baoyuan decoction in treatment chronic heart failure by network pharmacology molecular docking technology. There are 144 effective active ingredients 253 targets decoction. The key mainly include flavonoids such as quercetin, naringenin glazin. 240 intersecting between Baoyuantang failure, its core jun proto-oncogene, signal transducer activator transcription 3, tumor protein 53, factor p65, mitogen-activated kinase 14, estrogen receptor 1, etc. gene ontology kyoto encyclopedia genes genomes enrichment analysis results show that it involves 2475 biological processes, 104 cell components, functions 174 related signals pathway. It regulates evolutionary processes including nutritional response, inflammatory oxidative stress apoptosis pathway etc., through components cytoplasm, membrane synapse, exerts DNA binding factor, RNA polymerase II specific serine/ threonine activity, ubiquitin-like ligase binding, phosphatidylinositol 3 kinaseprotein B, Mitogen-activated Advanced glycation end products-receptor for AGE, Interleukin-17, apoptosis, cancer other signaling pathways play a role effect.